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Nicole C. Close

Nicole C. Close

President and Principal Biostatistician
EmpiriStat, Inc


Nicole C. Close is trained in Epidemiology/Biostatistics with 20 years of professional experience in designing and implementing clinical trials. Her passion for her field is expressed in the diligence and insightfulness she brings to each project, device and therapeutic area. After years in the industry, she founded her own company, EmpiriStat, in 2008 specializing in Biostatistics and trial design for regulatory submissions in the US, Europe and Asia. Dr. Close has served at and on DSMBs, as a panel review member for grants, and Board member for several clinical trial and statistical professional organizations. She is an avid lecturer at colleges and professional meetings, serves as a mentor for Entrepreneurs and undergraduates pursuing interests in the biology and mathematics area. Dr. Close was awarded Entrepreneur of the Year for Women in Technology in Washington, DC, and EmpiriStat has won several awards as Best Place to work and Best Small Business with the Chamber of Commerce. Dr. Close also enjoys scuba, international travel, and the Pittsburgh Steelers.

Research Interest

large-scale, multi-site data collection and statistical analysis activities